Platelets and polymorphonuclear leukocytes in experimental ocular inflammation in the rabbit eye
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Auteurs : RBID : ISTEX:417_1989_Article_BF02172900.pdfAbstract
Accumulation of111indium-oxine (111In)-labelled platelets and the kinetics of111In-labelled polymorphonuclear leukocytes (PMNLs) were studied in the anterior eye during neurogenic inflammation (induced by topical neutral formaldehyde) or after paracentesis in the rabbit, after formaldehyde irritation, 40 times more platelets were found in the aqueous humor 60 min later than in the control eyes and 400 times more after paracentesis. Platelets were found to be increased in the ciliary body, but not in the iris or choroid. Under light microscopy, some of the blood vessels in the ciliary processes were occluded and filled with red blood cells and platelets. The amount of PMNLs increased in the aqueous humor 15–20 h following formaldehyde irritation. After paracentesis, increased amounts of PMNLs were found in the iris and ciliary body 3–6 h later, while in the aqueous humor PMNLs were observed already 2 h. In the present study, increased amounts of111In-labelled platelets and PMNLs were demonstrated in the anterior eye during experimental ocular inflammation. This method provides a useful tool for evaluating the accumulation of cells or the cell kinetics in ocular tissues during experimental inflammation.
DOI: 10.1007/BF02172900
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Lehtosalo</name><affiliation wicri:level="1"><mods:affiliation>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name>Hannu Uusitalo</name><affiliation wicri:level="1"><mods:affiliation>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki, Finland</mods:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:417_1989_Article_BF02172900.pdf</idno><date when="1989">1989</date><idno type="doi">10.1007/BF02172900</idno><idno type="wicri:Area/Main/Corpus">000D70</idno><idno type="wicri:Area/Main/Curation">000D70</idno><idno type="wicri:Area/Main/Exploration">000472</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Accumulation of111indium-oxine (111In)-labelled platelets and the kinetics of111In-labelled polymorphonuclear leukocytes (PMNLs) were studied in the anterior eye during neurogenic inflammation (induced by topical neutral formaldehyde) or after paracentesis in the rabbit, after formaldehyde irritation, 40 times more platelets were found in the aqueous humor 60 min later than in the control eyes and 400 times more after paracentesis. Platelets were found to be increased in the ciliary body, but not in the iris or choroid. Under light microscopy, some of the blood vessels in the ciliary processes were occluded and filled with red blood cells and platelets. The amount of PMNLs increased in the aqueous humor 15–20 h following formaldehyde irritation. After paracentesis, increased amounts of PMNLs were found in the iris and ciliary body 3–6 h later, while in the aqueous humor PMNLs were observed already 2 h. In the present study, increased amounts of111In-labelled platelets and PMNLs were demonstrated in the anterior eye during experimental ocular inflammation. This method provides a useful tool for evaluating the accumulation of cells or the cell kinetics in ocular tissues during experimental inflammation.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="ec99e231b3d8d5fa179004acc8f789ead04afd5a"><titleInfo lang="eng"><title>Platelets and polymorphonuclear leukocytes in experimental ocular inflammation in the rabbit eye</title></titleInfo><name type="personal"><namePart type="given">Kari</namePart><namePart type="family">Krootila</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki, Finland</affiliation></name><name type="personal"><namePart type="given">Martti</namePart><namePart type="family">Syrjälä</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Blood Transfusion Service, Finnish Red Cross, Helsinki, Finland</affiliation></name><name type="personal"><namePart type="given">Juha I.</namePart><namePart type="family">Lehtosalo</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki, Finland</affiliation></name><name type="personal"><namePart type="given">Hannu</namePart><namePart type="family">Uusitalo</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Anatomy, Eye Research Laboratory, University of Helsinki, SF-00170, Helsinki, Finland</affiliation></name><typeOfResource>text</typeOfResource><genre>Laboratory Investigations</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1988-11-17</dateCreated><dateCaptured encoding="w3cdtf">1989-01-27</dateCaptured><dateValid encoding="w3cdtf">2005-08-31</dateValid><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">Accumulation of111indium-oxine (111In)-labelled platelets and the kinetics of111In-labelled polymorphonuclear leukocytes (PMNLs) were studied in the anterior eye during neurogenic inflammation (induced by topical neutral formaldehyde) or after paracentesis in the rabbit, after formaldehyde irritation, 40 times more platelets were found in the aqueous humor 60 min later than in the control eyes and 400 times more after paracentesis. Platelets were found to be increased in the ciliary body, but not in the iris or choroid. Under light microscopy, some of the blood vessels in the ciliary processes were occluded and filled with red blood cells and platelets. The amount of PMNLs increased in the aqueous humor 15–20 h following formaldehyde irritation. After paracentesis, increased amounts of PMNLs were found in the iris and ciliary body 3–6 h later, while in the aqueous humor PMNLs were observed already 2 h. In the present study, increased amounts of111In-labelled platelets and PMNLs were demonstrated in the anterior eye during experimental ocular inflammation. This method provides a useful tool for evaluating the accumulation of cells or the cell kinetics in ocular tissues during experimental inflammation.</abstract><relatedItem type="series"><titleInfo type="abbreviated"><title>Graefe's Arch Clin Exp Ophthalmol</title></titleInfo><titleInfo><title>Graefe's Archive for Clinical and Experimental Ophthalmology</title><partNumber>Year: 1989</partNumber><partNumber>Volume: 227</partNumber><partNumber>Number: 5</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1989-09-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic></subject><identifier type="issn">0721-832X</identifier><identifier type="issn">Electronic: 1435-702X</identifier><identifier type="matrixNumber">417</identifier><identifier type="local">IssueArticleCount: 20</identifier><recordInfo><recordOrigin>Springer-Verlag, 1989</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF02172900</identifier><identifier type="matrixNumber">Art13</identifier><identifier type="local">BF02172900</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>465</start><end>469</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, Berlin Heidelberg, 1989</recordOrigin><recordIdentifier>417_1989_Article_BF02172900.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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